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Objective: This research study aimed to evaluate two distinct methods for applying foliar fertilizers: agricultural drone application and manual backpack sprayer application (traditional method). Design/methodology/approach: A chemical foliar fertilizer (Bayfolan Forte), an organic fertilizer (Hormonamin), and a mixture of both were evaluated in maize. A maize crop was established, and two treatment applications were carried out at 44 and 64 days after sowing. The variables assessed included plant height, ear height, foliar nutrient concentration after each application, 1,000-grain weight, and grain yield. Results: Regarding nutrient absorption after foliar applications, Bayfolan, Hormonamin, and their mixture showed greater nutrient uptake than the control treatment (water). Moreover, among the application methods, a greater increase was observed when the treatments were applied using an agricultural drone. Findings/conclusions: Grain yield increased when foliar fertilizers were applied with an agricultural drone compared with manual backpack spraying.