Nanoparticle sterilization methods for biomedical applications in animals


R.A. Galicia-Gonzalez
M.E. Ortega-Cerrilla
C. Nava-Cuellar
L. Miranda-Jiménez
M. Ramírez-Mella
J.M. Ayala-Rodríguez


Animals, Parenteral application, Nanoparticles, Sterilization.


Objective: To review different nanoparticle sterilization methods for their use in biomedical applications in animals.

Approach: Sterilization is used to obtain a microorganism-free product without altering its physicochemical characteristics during its preparation, storage, or administration route. This review explores different sterilization methods and their advantages and disadvantages on the nanoparticle level.

Study limitations/implications: Nanoparticles are used in animal production, including their parenteral administration. Therefore, establishing the characteristics of different technologies applied to sterilize nanoparticles is essential to ensure the delivery of sterile products preventing health risks.

Conclusions: The use of nanotechnology in livestock production offers several advantages for animal nutrition, reproduction, and health, among other things. When nanoparticles must be sterilized, choosing the most suitable method is essential. This depends on the amount of product and its compound type because each technique has specific requirements that must be taken into account to be ready for potential changes in the structure and availability of the final product.

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